Overview

Effects of Levosimendan on Cellular Metabolic Alterations in Patients With Septic Shock

Status:
Unknown status

Trial end date:
2018-02-01

Target enrollment:
0

Participant gender:
All

Summary

To investigate changes in the concentration of glucose, lactate, pyruvate and glycerol in the extracellular fluid of the skeletal muscle following levosimendan administration in patients with septic shock.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Military Hospital of Tunis

Treatments:

Dobutamine
Simendan

Criteria

Inclusion Criteria:

- patients who fulfilled the criteria of septic shock that required norepinephrine (NE)
to maintain a mean arterial pressure (MAP) of at least 65 mm Hg despite appropriate
volume resuscitation (pulmonary arterial occlusion pressure [PAOP] = 12 to 18 mm Hg
and central venous pressure [CVP] = 8 to 12 mm Hg)

Exclusion Criteria:

- pregnancy, uncontrolled hemorrhage, terminal heart failure, significant valvular heart
disease, documented or suspected acute coronary syndrome, and a limitation on the use
of inotropes: left ventricle outflow obstruction, systolic anterior motion of the
mitral valve.