Effects of (Licochalcone A) and Paclitaxel on Human Oral Squamous Cell Carcinoma Cell Line
Status:
Unknown status
Trial end date:
2019-04-01
Target enrollment:
Participant gender:
Summary
Oral squamous cell carcinoma (OSCC) are considered as a one of the most malignant cancers. It
has prognosis due to its distant metastasis and obvious destruction which lead to low
survival rate.
The conventional treatment modalities such as surgery, radiotherapy and chemotherapy are only
the suitable strategies until now. Investigators cannot ignore the serious side effects of
chemotherapy such as gastrointestinal upset, bone marrow suppression which cannot be
overcome. For all these complications, there is a great need and demand to discover a new
agents and strategies for treating OSCC.
Licorice extract, especially Licochalcone A, is one of many natural extracts that have used
as a traditional in treatment of inflammation, microbial infections. Regarding antitumor
effect, Licochalcone A reveals interesting results in programmed cell death and apoptosis in
cancer cells such as prostate, bladder, colon and gastric cancer.