Effects of Liraglutide on Hippocampal Structure and Function in Aging Adults With Prediabetes
Status:
Completed
Trial end date:
2017-02-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate the effects of liraglutide on the memory and
attention of people with insulin resistance. Liraglutide is a medication that makes the body
more sensitive to insulin, and therefore may allow it to manage sugar more effectively.
The investigators are looking specifically at a region of the brain that is associated with
memory and attention, called the hippocampus, in order to see whether treatment this
treatment will change performance on memory and attention tasks. The investigators are also
taking an MRI of the brain to see whether there are changes to the size and shape of the
hippocampus after treatment.
All subjects in this study will be 50-70 years old and have pre- diabetes. Half of all
subjects will have a family history of dementia, while the other half will not.