Effects of Local Insulin on Varicose Ulcers for Wound Healing
Status:
Completed
Trial end date:
2020-02-15
Target enrollment:
Participant gender:
Summary
A randomized, split-plot, double-blind, placebo-controlled trial. The varicose ulcer is
divided into two (side A and B). Half of the wound's surface is treated locally with insulin
(Glargine) applied at an approx depth of 3-4 mm. Treatment with insulin is administered for 7
days. Biopsy specimens of the two sides are obtained on days 0 and 7. A thermographic
photograph of the wound is taken at days 0 and 7. The number of blood vessels and fibroplasia
is evaluated as the main outcome.