Effects of Long Acting Bronchodilators on CARDiac Autonomic Control in Chronic Obstructive Pulmonary Disease (COPD)

• Status: Completed
• Trial end date: 2021-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this interventional, randomized, double-blind, monocentric, cross-over study is to quantify the possible deleterious effect on the cardiac autonomic nervous system control of two long-acting anticholinergic bronchodilatators (tiotropium and glycopyrronium) and one beta-2 agonist long-acting bronchodilatator (indacaterol ) in patients with mild COPD.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centre Hospitalier Universitaire de Besancon
• Treatments: Bronchodilator Agents; Glycopyrrolate; Tiotropium Bromide

Criteria

Inclusion Criteria:

• patients with FEV1 / FVC <70%

Exclusion Criteria:

• beta blocker

• supraventricular rhythm disorder

• previous history of respiratory disease other than COPD

• diabetes

• autonomic dysfunction

• dysautonomia

• renal failure

• long-term oxygen therapy

• history of psychiatric illness