Effects of Low Dose Buprenorphine on Recovery After Hip or Knee Arthroplasty
Status:
Completed
Trial end date:
2015-10-01
Target enrollment:
Participant gender:
Summary
Buprenorphine is a highly lipophilic thebaine derivative that appears to have high affinity
for mu-, kappa-, and delta-opioid receptors and low affinity for opioid receptors like 1
-receptors. It acts as a partial agonist at the mu-opioid and as a partial agonist/antagonist
at the kappa-opioid, and as an antagonist at the delta opioid receptors. Buprenorphine has up
to two-fold duration of action and it is approximately 30-fold more potent when compared to
morphine.
Pain is a common problem in patients coming to joint arthroplastic surgery. Buprenorphine low
dose patches are recommended for treatment of moderate pain for example osteoarthritis pain.
It is known that well treated pain even preoperatively may prevent prolonged postsurgical
pain.
In the present study the effects of low dose buprenorphine on postoperative pain and recovery
were assessed.