Effects of Low-dose Esmolol on Myocardial Injury After Non-cardiac Surgery in Elderly Frail Patients

• Status: Recruiting
• Trial end date: 2026-12-30
• Target enrollment: 0
• Participant gender: All

Summary

This topic will focus on the following questions:

1. Part one: To clarify the relationship between preoperative frailty and myocardial injury (cTnT ≥0.03) after non-cardiac surgery in elderly patients; To further explore the predictive factors of myocardial injury after non-cardiac surgery （MINS） in elderly frail patients before operation.

2. Part Two: To explore the effect of low-dose esmolol on myocardial injury after non-cardiac surgery in frail elderly patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yongtao Sun
• Treatments: Esmolol

Criteria

Inclusion Criteria:

1. Age ≥ 65 years;

2. ASA: ⅰ-ⅳ;

3. Modified frailty index (mFI) ≥ 0.21;

4. Patients undergoing non-cardiac surgery.

Exclusion Criteria:

1. Refuse to participate;

2. Expected hospital stay <3 days;

3. Preoperative β-blocker therapy;

4. History of myocardial infarction or coronary artery disease;

5. Preoperative bradycardia (heart rate [HR] < 50 bpm) or arrhythmia;

6. Significant cardiac insufficiency (i.e., pulmonary artery pressure >18 mm Hg, cardiac index ≤ 2.2 L/min/m 2);

7. Severe valvular heart disease;

8. Severe lung disease (e.g. asthma or chronic obstructive pulmonary disease);

9. Patients with perioperative troponin elevation due to nonischemic causes (e.g., sepsis, pulmonary embolism, arrhythmia);

10. The same patient can only be included once, regardless of whether the reason for the second operation is related to the first cause.

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