Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients
Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
Background: The aim of this prospective study was to evaluate the effect of magnesium on the
reversal of rocuronium-induced neuromuscular block by sugammadex.
Methods: Eighty patients, aged 18 to 60 years, American Society of Anesthesiologists I-II,
undergoing elective gynecological surgery were enrolled. Anaesthesia was induced with
propofol and fentanyl and was maintained with 60% nitrous oxide and Oxygen in sevoflurane.
The magnesium group received 50 milligram/kilogram (mg/kg) Magnesium intravenous (iv) as a
bolus and 15 mg/kg/hour by continuous infusion until the completion of surgery. The placebo
group received the equivalent volume of isotonic saline. For intubation, 0.6 mg/kg rocuronium
was administered and 0.1 mg/kg was added when Train of four (TOF) counts reached 1 or more
during the procedure. At the end of the surgery at a TOF count of 1, 4 mg/kg sugammadex iv
was administered. Patients were observed until a TOF ratio of 0.9 was achieved.
Patient-controlled analgesia with intravenous morphine was used postoperatively.