Effects of Metformin vs Oral Contraceptives on CV Risk Markers in PCOS
Status:
Completed
Trial end date:
2006-10-01
Target enrollment:
Participant gender:
Summary
Cardiovascular risk factors cluster in hyperandrogenic women - including those presenting
with the polycystic ovary syndrome - in association with insulin resistance, obesity, and
other metabolic disorders.
The present clinical trial intends to compare the effects of oral contraceptives and
metformin on PCOS patients, focusing on classic and non-classic cardiovascular risk markers
and indexes of cardiovascular performance, in order to whether or not, as suspected by
previous data obtained in non-hyperandrogenic women, oral contraceptives worsen the
cardiovascular risk profile of PCOS women, favoring the use of metformin if the latter
actually ameliorates such a risk.