Effects of Methylphenidate (Ritalin®) on the Neural Basis of Anxiety
Status:
Completed
Trial end date:
2014-10-01
Target enrollment:
Participant gender:
Summary
In the present study, investigator will investigate the effects of methylphenidate (40 mg) on
mPFC activity in healthy male volunteers during fear extinction using functional magnetic
resonance imaging (fMRI). Additionally, investigators will examine the effects of
methylphenidate during aversive interoceptve arousal. The present study will help to identify
brain structures and networks involved in anxiety and will give insights for methylphenidate
as a possible adjunct to behavioral therapy for patients with anxiety disorders. Further,
this study may provide important information about the possible use of fMRI to help the
development of drugs for the treatment of anxiety disorders.