Effects of Methylprednisolone After Total Knee Arthroplasty

• Status: Completed
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to compare the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome after knee arthroplasty.

The hypothesis is that pre-operative methylprednisolone (125mg iv) will reduce pain and improve outcome.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hvidovre University Hospital
• Collaborator: Lundbeck Foundation
• Treatments: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria:

• Elective total knee arthroplasty

• Able to speak and understand danish

• Able to give informed consent

Exclusion Criteria:

• Alcohol or medical abuse

• Allergies to local anesthetics or methylprednisolone

• Age < 18 years

• Daily use of opioids or glucocorticoids

• Pregnancy or breastfeeding (fertile women)