This study is designed as a 3 week, randomized, double blind, placebo controlled, trial.
Olanzapine and modafinil will be titrated to 10mg and 200mg respectively. Feeding lab
assessments will be conducted at baseline and endpoint. Assessments of hunger/satiety,
kilocalories consumed and weight will be obtained. Plasma ghrelin and PYY3-36 levels will be
drawn at baseline and endpoint prior to breakfast and two hours post.
Study hypothesis: The modafinil/olanzapine group will gain less weight than the
olanzapine/placebo group over three weeks of drug intake.
Phase:
N/A
Details
Lead Sponsor:
Neuropsychiatric Research Institute, Fargo, North Dakota