Effects of Multimodal Analgesia on Serum MCP-1, BDNF, and MiRNA-124 in Hysterectomy Surgery
Status:
Not yet recruiting
Trial end date:
2022-06-30
Target enrollment:
Participant gender:
Summary
The inflammatory process is the main mechanism in the occurrence of acute postoperative pain.
It is also the main risk for the development of acute pain into persistent pain. Inflammation
occurs in the process of peripheral sensitization and central sensitization with various
inflammatory mediators. Postoperatively, there will be proliferation and activation of
microglia and astrocytes which will then activate inflammatory receptors and signaling
cascades of neurotransmitters, cytokines, and chemokines. There has been a lot of clinical
research evidence that multimodal analgesia can adequately treat acute pain and can prevent
the development of acute postoperative pain into persistent pain and chronic postoperative
pain, but the molecular mechanisms are not fully understood.