Effects of Nicotine Replacement and Repeated Cue Exposure on Cigarette Craving

• Status: Completed
• Trial end date: 2013-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether Cue Extinction Training will reduce relapse rates in cigarette smokers using the patch to quit.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: New York State Psychiatric Institute
• Treatments: Nicotine

Criteria

Inclusion Criteria:

• A DSM-IV Diagnosis of nicotine dependence with physiological dependence. Smoke at least 15 cigarettes daily for two years.

• Not interested in treatment.

• Medically healthy on the basis of physical examination and medical history, vital signs, EKG and laboratory tests, with a negative pregnancy test for females.

• Able to perform study procedures.

• Males or females between the ages of 21-60 years.

• Female participants agree to use an effective method of birth control during the course of the study.

Exclusion Criteria:

• A DSM-IV diagnosis of abuse or dependence on alcohol or drugs other than nicotine.

• Current Axis I diagnosis or current treatment with psychotropic medications (within last 3 months).

• Lifetime history of schizophrenia or other psychotic disorders, bipolar disorder, or anxiety disorders.

• Seeking treatment for nicotine dependence.

• Participants on parole or probation.

• History of significant recent violent behavior.

• Unstable medical condition, Blood Pressure > 150/90, Pregnancy.

• History of allergic reaction to nicotine patch.

• Participants with significant cardiac history (i.e. angina pectoris, bypass surgery, or coronary artery disease.)