Effects of Non-invasive Ventilation With Helium-oxygen Mixture in Premature Infants With Respiratory Distress Syndrome
Status:
Completed
Trial end date:
2018-12-01
Target enrollment:
Participant gender:
Summary
The use of a mixture of helium with oxygen (heliox) as a breathing gas may be beneficial due
to its unique physical properties, such as low density and high carbon dioxide (CO2)
diffusion coefficient. In previous studies in neonates with respiratory failure, conventional
ventilation with heliox was associated with improved oxygenation and selected respiratory
parameters. The use of heliox may increase the effectiveness of intermittent nasal positive
pressure ventilation (NIPPV), but knowledge about the effects of such therapy on newborns is
limited.The use of non- invasive neurally adjusted ventilatory assist (NIV-NAVA) allows
synchronization and assessment of electrical activity of the diaphragm (EaDI) during heliox
administration in premature babies with respiratory failure.