Effects of Nonintubated Versus Intubated General Anesthesia on Recovery After Thoracoscopic Lung Resection
Status:
Unknown status
Trial end date:
2016-10-01
Target enrollment:
Participant gender:
Summary
Lung cancer is the leading cause of cancer death in Taiwan and worldwide. With the
advancement of thoracoscopic technique, thoracoscopic surgery has emerged as a reasonable
option for the management of early-stage non-small cell lung cancer (NSCLC). Additionally,
current lung cancer screening policy recruits increasing number of candidates requiring
thoracoscopic lung resections because of lung nodules/tumors. Traditionally, intubated
general anesthesia with one-lung ventilation using a double-lumen endotracheal tube or an
endobronchial blocker has been considered mandatory in thoracoscopic surgery. However,
adverse effects of intubated general anesthesia are not negligible. Recently, a nonintubated
thoracoscopic technique has developed to reduce the adverse effects of intubated general
anesthesia with encouraging results. Nonetheless, the role of nonintubated technique in
thoracoscopic lung resection surgery in quality of postoperative recovery in not clear. As an
enhanced recovery is the major goal of modern minimally invasive surgery, the investigators
hypothesize that nonintubated thoracoscopic technique can facilitate and improve the recovery
quality after surgery. To this end, the investigators will recruit 300 patients in subgroups
including patients undergoing segmentectomy/lobectomy, wedge resection and geriatric patients
in this two-year project. Patients will be randomly allocated in nonintubated and intubated
groups and quality of recovery of all patients will be evaluated according the protocol of
Postoperative Quality of Recovery Scale. In the meantime, the preoperative and postoperative
cytokines will be compared between the groups as well as patients with different recovery
scales.