Effects of Nonsteroidal Anti-inflammatory Drug (NSAID) on Inflammatory Lesion of Axial Spondyloarthritis
Status:
Completed
Trial end date:
2018-06-05
Target enrollment:
Participant gender:
Summary
Axial Spondyloarthritis (SpA) is a kind of inflammatory arthritis which includes ankylosing
spondylitis. Common symptoms of axial SpA are inflammatory back pain, morning stiffness,
peripheral arthritis, enthesitis. Controlling aforementioned symptoms are one of the goal in
treatment, and another goal is preventing bony ankylosis of axial skeleton such as spine.
Ankylosis can limit range of motion and lower the quality of life.
Non-steroidal antiinflammatory drug (NSAID) and Tumor necrosis factor (TNF)-a inhibitor are
the current treatment options for axial SpA. These medications can improve pain and stiffness
of axial SpA patients, however preventing bony ankylosis is not proven. Current study showed
attenuating inflammation at early stage could prevent further bony destruction and ankylosis
in axial SpA. Present study is designed to discover the therapeutic effect of NSAID whether
NSAID could recover the early inflammatory bony change (bone marrow edema at MRI) and prevent
further bony change.