Effects of Omegas 3 and 6 on Alcohol Dependence

• Status: Completed
• Trial end date: 2008-06-01
• Target enrollment: 0
• Participant gender: Male

Summary

Context: The treatment of alcoholism is a challenge for psychiatrists and patients. Some studies have shown that alcohol alters the environment of the membranes, mainly by modifying their permeability through the lipid fraction. These lipids are known as essential fatty acids (EFA) because they are obtained only through the diet, as the human body is unable to synthesize them. Linolenic acid (LA), or omega 6, and alpha-linolenic acid (ALA), or omega 3, are polyunsaturated fatty acids (PUFAs). Finally, ethanol changes the absorption and metabolism of PUFAs, and it's supplementation may be helpful for alcohol dependence recovery.

Objective: to assess the effectiveness of PUFAs supplementation in the treatment of alcohol dependent patients.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Federal University of São Paulo
• Collaborators: Associacao Fundo de Incentivo a Psicofarmcologia; Fundação de Amparo à Pesquisa do Estado de São Paulo
• Treatments: Borage oil; Mineral Oil; Naltrexone

Criteria

Inclusion Criteria:

• severe alcohol dependence

• no history of allergic processes, hepatic, cardiovascular, renal, pulmonary, endocrine or neurological pathologies, as well as no history of psychiatric disorders, dependences other than alcohol and/or tobacco, and blood test results outside the reference range

Exclusion Criteria:

• history of allergic processes, hepatic, cardiovascular, renal, pulmonary, endocrine or neurological pathologies

• dependences other than alcohol and/or tobacco

• psychiatric disorders

• test laboratories results outside the reference range