Effects of Oxygen Supply After Lung Isolation in Thoracic Surgery
Status:
Completed
Trial end date:
2024-03-07
Target enrollment:
Participant gender:
Summary
The goal of this randomized clinical trial is to compare a liberal versus restrictive oxygen
supply (fraction of inspired oxygen, FiO2) strategy in patients scheduled for thoracic
surgery requiring one-lung ventilation during lung isolation. The primary and secondary
outcome parameters are:
- oxygenation of the blood after 30 minutes of one-lung ventilation, assessed by PaO2/FiO2
ratio
- time to lung collapse after start of one-lung ventilation
Participants in the control goup will receive an oxygen content of 100% before lung
isolation, which will be subsequently decreased to achieve normoxia or mild hyperoxia (PaO2
of 75-120 mmHg).
The intervention group will receive the previous, during two-lung ventilation set, oxygen
content and after lung isolation oxygen supply will be increased to secure adequate
oxygenation of the blood (PaO2 75-120 mmHg) during one-lung ventilation.
The investigators hypothesize, that a higher fraction of inspired oxygen may impede hypoxic
pulmonary vasoconstriction of the collapsed lung and thus decrease overall oxygenation
performance during one-lung ventilation. Secondary endpoint will be the time to lung
collapse, as a lower fraction of inspired oxygen and thus a higher nitrogen content may
impede lung collapse.