Effects of Oxytocin on Cognitive and Reactive Fear

• Status: Recruiting
• Trial end date: 2021-05-01
• Target enrollment: 0
• Participant gender: Male

Summary

The study examines the (sub)regional specificity of anxiolytic oxytocin (OXT) effects on emotional face processing and reactive and cognitive fear. Preliminary data indicate that the Receptor for Advanced Glycation End Products (RAGE) may regulate oxytocin transport into the brain. Thus, the study aims to replicate previous observations of oxytocin effects on the processing of fearful faces in the centro-medial amygdala and to assess whether a RAGE polymorphism (-374 T/A: rs1800624; TT vs. TA/AA), that has been shown to alter transcriptional activity, modulates anxiolytic OXT effects.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital, Bonn
• Treatments: Oxytocin

Criteria

Inclusion Criteria:

• RAGE polymorphism (-374 T/A: rs1800624; TT vs. TA/AA)

• healthy male volunteers

• right handed

Exclusion Criteria:

• current psychiatric illness

• current psychiatric medication or psychotherapy

• MRI contraindication (e.g. metal in body, claustrophobia)