Overview
Effects of PARP Inhibitor on Tumor Microenvironment in High-risk Endometrial Cancer Patients
Status:
Not yet recruiting
Not yet recruiting
Trial end date:
2024-03-31
2024-03-31
Target enrollment:
0
0
Participant gender:
Female
Female
Summary
This is a window study where treatment-naïve patients will receive olaparib before definitive treatment. The aim is to evaluate the DNA damage and inflammatory response after PARP inhibitor.Phase:
Early Phase 1Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
The University of Hong KongTreatments:
OlaparibCriteria
Inclusion Criteria:1. Patients must be capable of giving signed informed consent
2. Patients must be at least 18 years old
3. Patients must have newly diagnosed and histologically confirmed high-risk endometrial
cancer, including:
1. G3 endometrioid, any stage
2. Type 2 (such as serous, clear cell, carcinosarcoma), any stage
3. G1 endometrioid, stage 2 or beyond
4. The endometrial cancer should be visible on pre-treatment ultrasound, or endometrial
lining should be 5mm or above
5. An archived FFFE sample of endometrial biopsy or at least 8 unstained slides should be
available
6. Patients should have Eastern Cooperative Oncology Group (ECOG) performance score 0 to
1
7. Patients must have adequate bone marrow, renal, hepatic, thyroid and neurological
function within 28 days prior to administration of study treatment
8. Patients must be able to swallow oral medication
9. Patients must have a life expectancy of ≥ 16 weeks
10. Patients must either be postmenopausal or show evidence of non-childbearing status for
women of childbearing potential
Exclusion Criteria:
1. Patients with other malignancy unless curatively treated with no evidence of disease
for >= 5 years, are excluded.
2. Patients whose resting ECG indicating uncontrolled, potentially reversible cardiac
conditions, or patients with congenital long QT syndrome, are excluded.
3. Patients with myelodysplastic syndrome/acute myeloid leukaemia or with features
suggestive of MDS/AML, other hematological diseases such as venous or arterial
thrombosis and thrombocytopenia are excluded.
4. Patients with symptomatic uncontrolled brain metastases are excluded.
5. Patients who are unable to swallow orally administered medication and gastrointestinal
disorders are excluded.
6. Patients with immunocompromised condition, active hepatitis, or persistent toxicities
caused by previous cancer therapy, are excluded.
9. Concomitant use of known strong CYP3A inhibitors or inducer are excluded. 10. Patients
who have major surgery within 2 weeks, previous allogenic bone marrow transplant, are
excluded.
11. Patients with a known hypersensitivity to olaparib or any of the excipients of the
product are excluded.
12. Use of an investigational drug within 30 days or 5 half-lives, whichever is longer,
proceeding the first dose of study drug is not allowed.
13. Pregnant or breastfeeding women are excluded. 14. Patients who are judged by the
investigator to be unlikely to comply with study procedures, restrictions and requirements
are excluded.