Effects of PDE-5 Inhibition on Postprandial Hyperglycemia in Type 2 Diabetes
Status:
Terminated
Trial end date:
2011-11-01
Target enrollment:
Participant gender:
Summary
An increase of blood flow and capillary permeability decrease the impact of an endothelial
barrier for glucose and insulin allowing them to reach their target cells in peripheral
insulin sensitive organ in the human body. It is well known that insulin-resistant type 2
diabetes patients have an impaired blood flow in skeletal muscle and it is therefore
important to elucidate means to reverse this metabolic defect.
The investigators have in a recently published study in type 2 diabetes patients used a drug
against erectile dysfunction, the PDE-5 inhibitor tadalafil, with known effects on several
vascular territories, to increase muscle blood flow in type 2 diabetes patients who were
studied after fasting overnight.
The aim of this study is to test the hypothesis that tadalafil, compared to placebo,
increases muscle glucose uptake and lowers blood glucose following a mixed meal served to
type 2 diabetes patients.