Effects of Persistent Innate Immune Activation on Vaccine Efficacy
Status:
Terminated
Trial end date:
2018-11-01
Target enrollment:
Participant gender:
Summary
This study will investigate the effects of chronic HCV infection and corresponding innate
immune activation on the immune response to HBV vaccination. We will recruit chronic HCV
patients and healthy control patients for HBV vaccination. We will use RNA Sequencing
(RNA-Seq), a relatively new technology for simultaneously measuring the expression of all
genes, to determine patients' innate immune status, and learn how this innate immune
signature is related to HBV vaccine response. We will then explore the mechanisms by which
chronic HCV infection affects different immune cells and functions that are known to be
important for an effective HBV vaccine response. These studies will enhance our understanding
of the immune effects of chronic viral infection, establish factors that determine effective
vaccine responses, and help guide vaccination strategies for HCV patients and other
individuals with chronic inflammatory disease.
Phase:
Phase 4
Details
Lead Sponsor:
Rockefeller University
Collaborator:
National Institute of Allergy and Infectious Diseases (NIAID)