Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder
Status:
Not yet recruiting
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
This preliminary study is designed to evaluate mechanisms by which excitatory dorsolateral
prefrontal cortex (dlPFC) repetitive transcranial magnetic stimulation (rTMS) (vs. sham) and
pharmacological stress (vs. placebo) alter behavior in non-treatment seeking individuals with
opioid use disorder (OUD). Specific Aims are to (1) Evaluate how stress impacts domains of
behavior including (1a) executive function and (1b) opioid-seeking behavior; and (2)
Determine whether rTMS stimulation attenuates (2a) executive dysfunction, (2b)
stress-reactivity, and (2c) opioid-seeking in individuals with OUD not receiving treatment.