Effects of Pioglitazone, a PPARgamma Receptor Agonist, on the Abuse Liability of Oxycodone
Status:
Completed
Trial end date:
2014-04-01
Target enrollment:
Participant gender:
Summary
The ability of pioglitazone (PIO) to alter the effects of opioids in humans has not been
characterized in a controlled laboratory setting. Accordingly, the proposed investigation
seeks to examine the effects of PIO on oxycodone, one of the most commonly used and abused
opioid drugs in the U.S. (Davis et al., 2003). More specifically, the primary aim of this
investigation is to characterize the subjective effects of oxycodone under maintenance on
various doses of PIO (0, 15, and 45 mg) in non-dependent, prescription opioid abusers.
Secondary aims of the study are to examine the influence of PIO on the analgesic, cognitive,
and physiological effects of oxycodone.