Insulin resistance is often complicated with hypertension. AGE and inflammation play
important roles in insulin resistance. Some studies reported that pioglitazone, insulin
sensitizer, is effective for patients with insulin resistance, however, the mechanisms are
still unclear. The aim of this study to evaluate the effect of pioglitazone compared with
glimepiride on AGE, inflammatory cytokines and cardiac markers (BNP and echo) in hypertensive
patients during oral glucose tolerance test.