Effects of Post-Session Supplemental Hydromorphone on Drug Seeking Behavior in Opioid Dependent Individuals

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether knowledge of post-session hydromorphone (HYD) availability reduces drug seeking behavior in heroin dependent individuals.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Wayne State University
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Analgesics, Opioid; Hydromorphone

Criteria

Inclusion Criteria:

• Opioid dependent, as determined by the structured clinical interview for DSM-IV (SCID) and Addiction Severity Index (ASI)

• Positive urine test for opiates

• Willing to use an adequate form of contraception for the duration of the study

• Reads and writes English

Exclusion Criteria:

• Psychiatric illness, as determined by the DSM-IV criteria

• History of or current neurological disease, including structural abnormalities, seizures, infection, peripheral neuropathy, and head traumas

• History of cardiovascular disease, myocardial infarction, chest pain, or edema

• Systolic blood pressure greater than 160 mm Hg or less than 95 mm Hg; PR diastolic blood pressure greater than 95 mm Hg

• Pulmonary disease, including obstructive pulmonary disease, cor pulmonale, tuberculosis, and asthma

• Systemic disease (e.g., endocrinopathies, liver or kidney failure, myxedema, hypothyroidism, Addison's disease, autoimmune disease)

• Current alcohol or sedative drug dependence

• Pregnant or breastfeeding

• Currently receiving treatment for opioid dependence

• Known phobia of injections