Effects of Prophylactic Desmopressin on Blood Coagulation Parameters in Heart Valve Surgery

• Status: Unknown status
• Trial end date: 2017-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is evaluate the effect of prophylactic desmopressin on blood coagulation parameters and postoperative bleeding in patients undergoing valve cardiac surgery with cardiopulmonary bypass.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Instituto do Coracao
• Treatments: Deamino Arginine Vasopressin

Criteria

Inclusion Criteria:

• Valve cardiac surgery with cardiopulmonary bypass.

• Written informed consent

Exclusion Criteria:

• Reoperative valve surgery

• Hematocrit < 35%

• Ventricular dysfunction (EF < 40%)

• Infection

• Body mass index > 35

• Renal impairment (Creatinin > 2mg/dL)

• Antiplatelet administration within 10 days preceding study surgery

• Participation in another interventional clinical study within 30 days

• Known or suspected hypersensitivity to the desmopressin

• Coagulopathy (INR > 1.5)