Effects of Quetiapine on Sleep and Next Day Alertness in People With Obstructive Sleep Apnea
Status:
Not yet recruiting
Trial end date:
2024-12-01
Target enrollment:
Participant gender:
Summary
Quetiapine is medication used to treat schizophrenia and bipolar disorder. Increasingly, low
doses of quetiapine are prescribed "off-label" for insomnia. Quetiapine increases sleep
duration with fewer interruptions, and people report feeling more rested. This accounts for
why it is popular to prescribe for insomnia. Insomnia and obstructive sleep apnea (OSA) share
many symptoms and differential diagnosis can be difficult. While quetiapine may improve sleep
and breathing in certain people (i.e in light sleepers) an initial study indicated that
quetiapine caused breathing disturbances in healthy individuals. Effects in OSA are unknown.
In this placebo-controlled double blind study, participants with mild-moderate OSA will spend
2 nights in the sleep lab, one with quetiapine at a dose commonly prescribed for insomnia and
one with placebo. The investigators will assess participants sleep by standard clinical sleep
study, and morning alertness using questionnaires, reaction tests, and a driving simulator
test.