Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study)
Status:
Completed
Trial end date:
2016-03-01
Target enrollment:
Participant gender:
Summary
Numerous trials support the efficacy and safety of volatile anesthetic agents, namely
inhalation of sevoflurane through dedicated devices, for the sedation of ICU patients.
Several preclinical studies have shown that sevoflurane inhalation improves gas exchange and
decreases pulmonary and systemic inflammation in experimental models of acute respiratory
distress syndrome (ARDS).
The purpose of our prospective monocentric, randomized, controlled trial is to evaluate the
effects of an early 48-hour sevoflurane inhalation on gas exchange and inflammation in
patients with ARDS.