Effects of Salsalate on Prandial-Induced Vascular Inflammation After Spinal Cord Injury (SCI)

• Status: Completed
• Trial end date: 2012-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The overall study objectives are to examine whether:

1. Persons with spinal cord injury (SCI) having elevated body mass are at greater cardiovascular disease (CVD) risk for fasting and postprandial lipidemia, glycemia, and vascular inflammation than persons with SCI having 'normal' body mass, and

2. An inexpensive, low-risk, widely-available pharmacotherapy safely reduces CVD risks associated with fasting and postprandial lipidemia, glycemia, and vascular inflammation.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Miami
• Treatments: Salicylsalicylic acid; Sodium Salicylate

Criteria

Inclusion Criteria:

• SCI resulting in tetraplegia at C3-C7

• injury for more than one year

Exclusion Criteria:

• 1. any recent dietary or other lifestyle changes;

• 2. diabetes or inflammatory medical conditions;

• 3. a pressure ulcer;

• 4. lung or bladder infection;

• 5. undiagnosed illness or fever;

• 6. recent surgery;

• 7. stomach ulcer or a history of stomach upset when taking aspirin or medicines like aspirin, or ,

• 8. currently taking medicines used for pain or inflammation (aspirin and non-steroidal anti-inflammatory drugs, corticosteroids), blood vessel diseases (statins or fibric acid derivatives), blood clotting disorders (Coumadin, Plavix), infections (antibiotics), diabetes (Metformin), and burning 'central' pain (voltage regulators).