Effects of Sedation on Spinal Anesthesia-induced Maternal Hypotension
Status:
Completed
Trial end date:
2015-02-01
Target enrollment:
Participant gender:
Summary
Background: This study was designed to investigate the effect of sedation on the occurrence
of maternal hypotension in preoperatively anxious parturients undergoing urgent category-1
Cesarean section (C/S) under spinal anesthesia.
Methods: After institutional ethics committee approval, prospectively collected data of 1824
parturients undergoing C/S were reviewed. Parturients with high preoperative anxiety scores
(visual analogue scale for anxiety (VAS-A)≥70) undergoing C/S under spinal anesthesia with
thiopental (Group S=49) and without any other type of sedation (Group NS=53) were included in
the analysis. Hemodynamic parameters were documented and maximum systolic arterial pressure
(SAP) reductions from the baseline after spinal anesthesia were calculated. Incidences of
hypotension (SAP≥30% decrease from baseline or <100 mmHg) and bradycardia (HR<55 beats/min),
and related-ephedrine and -atropine requirements were noted. Our primary endpoint was to
compare the maximum SAP reductions from the baseline values in Groups S and NS. Secondary
endpoints were incidences of hypotension and bradycardia, required ephedrine and atropine
doses, newborn Apgar scores at 1st and 5th min.