Effects of Sertraline on Brain Connectivity in Adolescents With OCD

• Status: Completed
• Trial end date: 2017-01-31
• Target enrollment: 0
• Participant gender: All

Summary

The investigators will examine how treatment with sertraline for 12 weeks impacts frontal-striatal-thalamic circuitry (FSTC) in this OCD sample.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Minnesota; University of Minnesota - Clinical and Translational Science Institute
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Sertraline

Criteria

Inclusion Criteria (OCD):

• OCD as the primary Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) diagnosis based on the Anxiety Disorders Interview Schedule (ADIS) for DSM-IV, Child Version

• Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) score of greater than 15

Exclusion Criteria (OCD):

• lifetime diagnosis of bipolar disorder, schizophrenia, or substance abuse/dependence on ADIS

• Intelligence Quotient (IQ) < 80 on Wechsler Abbreviated Scales of Intelligence (WASI)

• positive urine drug screen

• MRI-incompatible features (e.g., metal implants, claustrophobia)

• current or recent trial of psychotropic medication (within the past 4 8 weeks or past 6 12 weeks for fluoxetine)

• non-response in > 2 selective serotonin reuptake inhibitor (SSRI) trials of adequate dose/duration

• positive pregnancy test

• history of seizure disorder or serious head injury

Inclusion Criteria (Controls):

• Healthy 8-17 year olds

Exclusion criteria (controls):

• No psychiatric diagnoses

• No immediate family history of OCD