Effects of Short-term Intensive Insulin Therapy in Newly Diagnosed Type 2 Diabetes Patients
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
It is well known that Long-term hyperglycemia (also known as glucose toxicity) contribute to
impairment in islet β-cell function and development of insulin resistance. A growing body of
evidence also indicates that this impairment inβ-cell function and insulin action could be
restored after hyperglycemia is corrected by short-term intensive insulin therapy. In this
study, we are determined to use the golden standard of insulin sensitivity evaluation in
vivo-hyperinsulinemia euglycemic glucose clamp-to estimate insulin resistance improvement in
patients before and after intensive insulin therapy, investigate first phase insulin
secretion to evaluate β-cell function, examine the changes in insulin resistance and insulin
secretion resulting from normalization of plasma glucose levels in both lean and obese
patients by insulin pump therapy.