Effects of Smoked Marijuana on Neuropathic Pain

• Status: Completed
• Trial end date: 2006-02-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine if smoking marijuana will reduce neuropathic pain without causing too much drowsiness or feeling "too dopey".

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Center for Medicinal Cannabis Research

Criteria

Inclusion Criteria:

• Able to understand English

• Age greater than 18 and less than 70

• VAS greater than 3/10

• History of previous marijuana use (i.e., avoidance of marijuana naive subjects)

• Negative urine drug screening test

• Nerve Injury a.k.a. Complex Regional Pain Syndrome Type II OR

• Complex Regional Pain Syndrome Type I OR

• Neuropathic pain due to confirmed bilateral distal peripheral neuropathy associated with Diabetes I or II, focal nerve injury, postherpetic neuralgia, spinal cord injury with incomplete myelopathy, central pain following a stroke or focal brain lesion, or clinical definite multiple sclerosis of at least 3 months duration.

Exclusion Criteria:

• Presence of another painful condition of greater severity than the neuropathic pain condition which is being studied

• Unstable Type 1 or 2 diabetes defined as blood glucose more than 156 mg/dl

• For diabetic subjects maintained on insulin with a stable blood glucose more than 156 mg/dl, a hemoglobin A1C level of more than 0.11 (normal range, 0.048-0.067)

• History of traumatic brain injury

• History of schizophrenia or a past or current history of a serious psychiatric disorder that is currently not well controlled with medications

• Uncontrolled medical condition - coronary artery disease, hypertension, cerebrovascular disease, asthma, TB, COPD, opportunistic infection, malignancy requiring active treatment

• Active substance abuse (alcohol or injection drugs)

• Current use of marijuana (within 30 days of randomization) as determined by urine screening