Autosomal dominant polycystic kidney disease (ADPKD) is associated with early onset
hypertension and left ventricular (LV) hypertrophy. Since LV hypertrophy is associated with
LV diastolic function impairment, we aimed to assess the changes over time of LV diastolic
function in ADPKD patients and whether they were affected by the treatment with the
somatostatin analogue, octreotide.
35 ADPKD patients (14 males) aged 34±8 years (mean glomerular filtration rate 82±26
mL/min/1.73m2) were randomly assigned to 36 month treatment with placebo (n=18) or octreotide
(n=17). Clinical and echocardiography parameters were evaluated at baseline and study end. LV
mass (M) and ejection fraction (EF) were calculated according to Devereux formula and biplane
Simpson's algorithm, respectively. LV filling was assessed by mitral and pulmonary vein flow
velocity curves and mitral annulus early diastolic velocity peak (Ea) by tissue Doppler
imaging.