Effects of Steroid Injection With Percutaneous Needle Aponeurotomy in Dupuytren's Contracture
Status:
Completed
Trial end date:
2013-06-01
Target enrollment:
Participant gender:
Summary
Background:
Dupuytren's contracture is a common hand problem that causes certain fingers to bend towards
the palm. Patients with this condition cannot perform daily activities and many are unable to
work. It is usually treated by an operation to straighten the fingers followed by therapy if
the angle that the fingers are bent at is large enough. However, no treatment has been able
to completely prevent the angle from persisting.
Objective:
This study is designed to examine whether or not the use of a drug in combination with
surgery will improve the angle at which the fingers are bent more than surgery alone.
Hypothesis:
Subjects who receive triamcinolone acetonide will have straighter fingers compared with
subjects who only have the operation and no triamcinolone acetonide at both 3 months and 6
months after the operation.
Methods:
Eligible patients interested in having the operation to treat Dupuytren's contracture will be
asked if they would like to join the study. Subjects will be randomly placed into one of two
groups: the steroid injection group or the control group. Subjects will have a pre-operative
visit, the surgery, and follow-ups at 6 weeks, 3 months and 6 months. All subjects will have
the operation, but only those in the steroid injection group will receive an injection of the
drug. During the 6 week and 3 month follow-ups, subjects in the steroid injection group may
receive another injection if their fingers are still bent. Angles are measured at the
pre-operative visit and at 3 and 6 months. The change in angle from before to after and any
differences in the groups, in time points and interactions between the two will be analyzed.