Effects of Tinzaparin on Cardio-vascular Outcomes and on Blood Lipids in Diabetic Patients on Chronic Hemodialysis
Status:
Withdrawn
Trial end date:
2017-01-01
Target enrollment:
Participant gender:
Summary
Low molecular weight heparin (LMWH) provides a safe and effective alternative to UFH for
hemodialysis anticoagulation. While unfractionated (UF) heparin has been implicated in
hyper-lipidemia, the effect of LMWHs on the lipid profile in non-diabetic patients on chronic
hemodialysis remains controversial. The effect of LMWH in diabetic patients, a high risk
group for developing hyper-lipidemia and cardio-vascular disease, has not been studied.
The study intends to examine the long-term effects of the replacement of UFH by LMWH
(tinzaparin sodium) on cardio-vascular outcomes and on lipoprotein profiles in a large group
of diabetic patients stable on HD.