Effects of Tofacitinib vs Methotrexate on Rheumatoid Arthritis Interstitial Lung Disease
Status:
Recruiting
Trial end date:
2024-11-30
Target enrollment:
Participant gender:
Summary
Pulmonary abnormalities are present in up to 60% of patients with early rheumatoid arthritis
(RA), and up to 10% of the patients will develop clinical interstitial lung disease (ILD).
Recent data indicate that inhibition of Janus kinase is beneficial for this extra-articular
manifestation. Our goal is to determine whether tofacitinib is an effective and safe
treatment, compared to standard-of-care methotrexate, for subclinical and clinical ILD in
patients with early RA. The study also explores disease mechanisms in lungs and joints, to
identify potential biomarkers for diagnosis, prognosis, and response to treatment of RA-ILD.