The rationale of this study is to investigate the effects of topical diclofenac on tumor
metabolism in the treatment of actinic keratoses in immunocompetent and immunocompromised
patients.
Study hypothesis is that topical diclofenac lowers lactate level in skin biopsies of actinic
keratoses. Planned number of patients is 38.
This study is a monocenter study investigating the effects of 3% diclofenac in 2.5%
hyaluronic acid gel on tumor metabolism in the treatment of actinic keratoses. Treatment
duration is 3 months. Skin biopsies will be obtained before treatment, at the end of the
treatment and four weeks after the treatment. Control biopsies at visit 1 and 3 are performed
in healthy, sun damaged and untreated skin. Evaluation of efficacy will be performed at the
end of the treatment and four weeks after the treatment.
Duration of treatment is 3 months (±4 weeks). Approximately 0,5g Solaraze® 3% gel is applied
on a 5cm x 5cm lesion. Solaraze® 3% gel is applied twice daily on the study lesions.