Effects of Topical Gentamicin on the Prevention of Peritoneal Dialysis Related Infection

• Status: Recruiting
• Trial end date: 2023-05-31
• Target enrollment: 0
• Participant gender: All

Summary

Peritoneal dialysis-related infection is a complication that leads to peritoneal dialysis catheter removal or patient death. The present study aimed to investigate peritoneal dialysis-related infection, causative pathogens resulting in topical 2% mupirocin ointments period compare with 0.1% gentamicin cream period. Rate of catheter removal, time to first peritoneal dialysis-related infection after apply gentamicin cream.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Phramongkutklao College of Medicine and Hospital
• Collaborator: Silpakorn University Faculty of Pharmacy
• Treatments: Gentamicins; Mupirocin

Criteria

Inclusion Criteria:

• Age greater than or equal to 20 years

• End stage renal disease patients on peritoneal dialysis follow up at Phramongkutklao hospital's peritoneal dialysis clinic between January 1, 2021 to March 31, 2023

• Start peritoneal dialysis or follow up at Phramongkutklao hospital's peritoneal dialysis clinic at least 90 days before recruited

• Use topical mupirocin ointment for prevention of peritoneal dialysis-related infection between January 1, 2021 to December 31, 2021

• Can be used LINE application throughout the study

Exclusion Criteria:

• Allergy to gentamicin or components

• Previous systemic antibiotics use within 90 days before recruited

• Previous peritoneal dialysis-related infection within 28 days before recruited

• Immunosuppressants used

• Prospective follow up less than 2 months

• Don't sign informed consent