Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
Status:
Recruiting
Trial end date:
2025-12-01
Target enrollment:
Participant gender:
Summary
The study team's prior research has shown that dysfunction of a specific nerve, called the
vagus nerve, is associated with small intestinal bacterial overgrowth (SIBO), and that SIBO
is associated with signs of inflammation in the blood of people living with HIV (PLWH). This
research will explore pathways linking vagal dysfunction to inflammation in HIV, focusing on
the gastrointestinal tract, and study whether a medication called pyridostigmine and
stimulation of the vagus nerve are beneficial therapies.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Icahn School of Medicine at Mount Sinai
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)