Intermittent hemodialysis/diafiltration is a current renal replacement therapy (RRT)
institued for ICU patients with AKI. For a better clinical tolerance, iinternational
guidelines advise to use cold dialysate, increase duration session, decrease blood and
dialysate flows, and increase level of sodium dialysate concentration (≥ 145mmol/l). Indeed,
the use of a Na concentration dialysate > 145 mmol/l improves intradialytic hemodynamic
tolerance but it may also induce fluid overload by the transfert of sodium from the dialysate
compartment to the blood. Yet, fluid overload has been strongly associated with mortality in
critically ills. The investigators hypothesized that the use of a level in sodium dialysate
at 140 mmol/l with slow low efficiency daily dialysis-filtration (SLEDD-f) will permit a fair
intradialytic hemodynamic tolerance without the adverse effect of intradiaclytic Na loading
from the dialysate. Two randomized groups of ICU AKI patients treated by SLEDD-f will be
compared in terms of intradialytic hemodynamic tolerance and overload accordong to 140 or 145
mmol/l of Na in the dialysate