Effects of Vitamin B1 in Type 1 Diabetic Patients

• Status: Completed
• Trial end date: 2011-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether benfotiamine supplementation can reduce markers of microvascular complications in type 1 diabetic patients.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Aker
• Collaborator: The Research Council of Norway
• Treatments: Benphothiamine; Thiamine

Criteria

Inclusion Criteria:

• Type 1 diabetes (of at least 15 years duration) as assessed by medical history.

Exclusion Criteria:

• Macroalbuminuria

• Symptomatic gastroparesis. Diabetic nephropathy with a creatinine clearance less than 60 cc/min.

• Evidence of chronic infection.

• History of any malignancy.

• Any chronic medical condition that unduly increases the risk for the potential enrollee as judged by study investigators.

• Pregnancy, breastfeeding or planned pregnancy within two years.

• Supplementation with thiamine > 2mg per day and/or alpha-lipoic acid

• Chronic alcoholism/alcohol abuse.