Effects of Vitamin C Administration on Extravascular Lung Water in Patients With Severe Features of Preeclampsia

• Status: Completed
• Trial end date: 2019-06-27
• Target enrollment: 0
• Participant gender: Female

Summary

The objective of the study is to determine whether administration of vitamin C (1.5g/6 hours) in the first three days post-partum reduces the amount of extravascular lung water assessed by lung ultrasound in patients with severe preeclampsia.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Medical Centre Ljubljana
• Treatments: Ascorbic Acid; Vitamins

Criteria

Inclusion Criteria:

Singleton pregnancy with severe featutes of preeclampsia (any of the following):

• Systolic blood pressure of 160 mm Hg or higher, or diastolic blood pressure of 110 mm Hg or higher on two occasions at least 4 hours apart while the patient is on bed rest (unless antihypertensive therapy is initiated before this time)

• Thrombocytopenia (platelet count less than 100x109/L)

• Impaired liver function as indicated by abnormally elevated blood concentrations of liver enzymes (to twice normal concentration), severe persistent right upper quadrant or epigastric pain unresponsive to medication and not accounted for by alternative diagnoses, or both

• Progressive renal insufficiency (serum creatinine concentration greater 97 µmol/L or a doubling of the serum creatinine concentration in the absence of other renal disease)

• Pulmonary edema

• New-onset cerebral or visual disturbances