Effects of Vitamin D on Renal Blood Flow, Proteinuria and Inflammation in Patients With Chronic Kidney Disease
Status:
Withdrawn
Trial end date:
2013-08-01
Target enrollment:
Participant gender:
Summary
Active forms of vitamin D and its analogs are used to treat elevated parathyroid hormone
levels and bone disease in chronic kidney disease (CKD). More recent animal and human studies
suggest that treatment with vitamin D may be associated with reduction of inflammation and
urinary protein loss as well as reduction the activity of the renin angiotensin system (RAS)
in addition to its effects on the bone metabolism. The investigators of this study have used
the new technique of contrast enhanced ultrasound (CEU) to measure the flow of blood to the
kidney in other human studies. In this study, the investigators will investigate if 3 month
of treatment with an active form of vitamin D in individuals with kidney disease and high
parathyroid hormone levels would reduce protein loss in the urine. The investigators will
also look at the potential changes in blood flow to the kidney using CEU, kidney function
(GFR), inflammation and activity of RAS in response to treatment with active form of vitamin
D. Finally, they will examine the association between reduction of protein loss in the urine
as shown in other studies with any of the other factors measured (e.g, change in blood flow
or inflammation).