Effects of Yohimbine and Naltrexone on Sexual Function
Status:
Completed
Trial end date:
2004-04-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate the safety and effectiveness of the drugs yohimbine
and naltrexone in treating men with erectile dysfunction (ED) (the inability to achieve or
maintain penile erection for satisfactory sexual performance).
ED is a medical and psychological problem that is usually associated with increased age.
Evidence suggests that specific neurotransmitter systems are involved in the regulation of
sexual function. Yohimbine and naltrexone are drugs that may influence these neurotransmitter
systems. This study will use different doses of yohimbine and fixed doses of naltrexone to
determine their effectiveness in treating ED.
Participants in this study will be screened with a medical history, physical examination,
blood and urine tests, and an electrocardiogram (ECG). The study will consist of three
outpatient visists.