Effects of a Cyclic NSAID Regimen on Levels of GCF PGE-E2 and IL-1beta
Status:
Completed
Trial end date:
2004-12-01
Target enrollment:
Participant gender:
Summary
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for inflammation control and
pain relief. However, while adjunct use of NSAIDs is avoided for periodontal therapy because
of related side effects, cyclic administration of NSAIDs may reduce or eliminate these
effects. The investigators evaluated the effect of a cyclic diclofenac potassium regimen on
clinical parameters and levels of prostaglandin E2 (PGE2) and interleukin-1beta (IL-1beta) in
the gingival crevicular fluid (GCF) of subjects with periodontitis. Forty-one subjects with
moderate to chronic periodontitis (33 men, 8 women) were divided into two groups (test and
control) after initial periodontal therapy. During this 6-month, randomized, double-blind,
placebo-controlled study, test (n = 28) and control (n = 13) groups were administered a
cyclic regimen of diclofenac potassium (50 mg, twice daily) or placebo. Clinical measurements
of disease severity and GCF sample collections were made at baseline, 2, 4 and 6 months. GCF
levels of PGE2 and IL1-1beta were determined using EIA and ELISA kits, respectively.