Effects of a GLP-1 Receptor Agonist on Functional Activation and Connectivity of the Brain

• Status: Completed
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The aims this study is to explore the effect of a GLP-1 receptor agonist on the degree of brain activation and connectivity obtained by functional magnetic resonance imaging in lean and obese type 2 diabetes

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Collaborator: Seoul National University
• Treatments: Glucagon-Like Peptide 1; Lixisenatide

Criteria

Inclusion Criteria:

• BMI ≤ 23kg/m2 or BMI ≥ 26kg/m2

• participants with diabetes treated by diet or oral antidiabetic drug, HbA1c less than 8.5%

Exclusion Criteria:

• Those who diagnosed by Type 1 diabetes

• History of insulin therapy

• Aspartate aminotransferase(AST) or Alanine transaminase(ALT) >2.5 times of upper normal reference range

• Estimated Glomerular Filtration Rate(eGFR) <30 mL/min/1.73m2

• Those who can't be performed MRI