Overview
Effects of a Range of Naltrexone Doses in Combination With Smoked Marijuana
Status:
Completed
Completed
Trial end date:
2010-08-01
2010-08-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
The purpose of this study is to determine if the subjective effects of marijuana will be decreased by low-doses (< 25 mg) of naltrexone and increased by high-doses (> 50 mg) of naltrexone.Phase:
Phase 2Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
New York State Psychiatric InstituteCollaborators:
National Institute on Drug Abuse (NIDA)
Research Foundation for Mental Hygiene, Inc.Treatments:
Naltrexone
Criteria
Inclusion Criteria:- Current marijuana use
- Able to perform study procedures
- 21-45 years of age
- Women practicing an effective form of birth control
Exclusion Criteria:
- Current, repeated illicit drug use (other than marijuana)
- Presence of significant medical illness (e.g., diabetes, cardiovascular disease,
hypertension, examination, laboratory hepatitis, clinically significant laboratory
abnormalities, tests, 12-lead ECG, Mantoux test LFTs > 3x upper limit of normal)
- History of heart disease
- Request for drug treatment
- Current parole or probation
- Pregnancy or current lactation
- Recent history of significant violent behavior
- Previous adverse reaction to naltrexone
- Major current Axis I psychopathology Psychiatric interview (e.g., major depressive
disorder, bipolar disorder, suicide risk, schizophrenia)
- Current use of any prescription or over-the-counter medication